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Beilstein J. Org. Chem. 2012, 8, 1293–1302, doi:10.3762/bjoc.8.147
Graphical Abstract
Figure 1: Biologically active benzofused sultams.
Scheme 1: Proposed library generation by microwave-assisted intermolecular SNAr diversification reaction.
Scheme 2: Utilization of a reaction pairing strategy for the synthesis of benzoxathiazocine 1,1-dioxides core...
Figure 2: Benzoxathiazocine 1,1-dioxides 1–8 and amine library building blocks {1–10}.
Figure 3: (i) Simple cartoon of the library compounds, with a core of MW ~ 80, based on Lipinski’s rules (MW ...
Figure 4: Distribution of 80 compounds (colored spheres) relative to the set of 771 known orally available dr...
Figure 5: Comparison of a small set of our representative compounds versus two sultams synthesized by our gro...
Figure 6: Three representative compounds with high QED values.
Figure 7: Representation of Z-scores for the 80 compounds.